UltraBiotic Akkermansia Plus Supplementation UltraBiotic Akkermansia Plus is a specially formulated probiotic supplement designed to support overall gut health, immune function, and metabolic balance. This supplement features a potent blend of scientifically backed bacterial strains that target the gut microbiome to support a healthy balance of beneficial bacteria. Each ingredient has been carefully selected for its unique properties and mechanisms of action, contributing to the supplement’s comprehensive benefits. UltraBiotic Akkermansia Plus leverages these targeted mechanisms to offer comprehensive support for gut health, healthy body composition, and metabolic health, making it a valuable addition to a holistic health regimen. Benefits of supplementing with UltraBiotic Akkermansia Plus may include: • Supports healthy glucose metabolism • Supports healthy weight management • Promotes colon health • Supports a balanced gut microbiome • Supports digestive health • Promotes healthy immune function How UltraBiotic Akkermansia Plus Works Bifidobacterium animalis HN019: This strain enhances gut health by improving bowel regularity and supporting a healthy immune system.1-3 It works by adhering to the intestinal mucosa and supporting the body’s immune response.4 Additionally, it helps maintain a healthy gut barrier, which is crucial for preventing the translocation of harmful substances into the bloodstream, thereby supporting a healthy inflammatory response.5 Bifidobacterium animalis B420: This strain aids in weight management and supports metabolic health by influencing gut microbiota composition and promoting the production of short-chain fatty acids (SCFAs) that support energy metabolism.6,7 It also helps with healthy body composition by supporting intestinal barrier function and promoting healthy inflammatory markers.8,9 NON-GMO GLUTEN-FREE DAIRY-FREE VEGETARIAN CGMP FACILITY CGMP For more information, visit: www.nutridyn.com Rev. 8/24 ND1194 ©2024 NutriDyn References: 1. Van Syoc EP, Damani J, DiMattia Z, et al. Adv Nutr. 2024;15(1):100137. 2. Takahashi S, Anzawa D, Takami K, et al. Biosci Microbiota Food Health. 2016;35(4):163-171. 3. Chen A-C, Fang T-J, Ho H-H, et al. Front Nutr. 2022;9:922993. 4. Gopal PK, Prasad J, Gill HS. Nutr Res. 2003;23(10):1313-1328. 5. Cheng J, Laitila A, Ouwehand AC. Front Nutr. 2021;8:790561. 6. Uusitupa HM, Rasinkangas P, Lehtinen MJ, et al. Nutrients. 2020;12(4):892. 7. Wastyk HC, Perelman D, Topf M, et al. Gut Microbes. 2023;15(1):2178794 8. Stenman LK, Waget A, Garret C, et al. Diabetol Metab Syndr. 2015;7;75. 9. Stenman LK, Lehtinen MJ, Meland N, et al. EBioMedicine. 2016;13:190-200. 10. Fong F, Kirjavainen P & El-Nezami H. Sci Rep. 2016;6:22845. 11. Ludwig IS, Broere F, Manurung S, et al. Front Immunol. 2018;9:1546. 12. Salemi R, Vivarelli S, Ricci D. et al. J Transl Med. 2023;21:195. How UltraBiotic Akkermansia Plus Works Continued Lactobacillus rhamnosus GG: Renowned for its immune-enhancing properties, Lactobacillus rhamnosus GG supports gut health by adhering to the intestinal mucosa, enhancing the integrity of the gut barrier, and supporting a healthy gut immune response.10,11 This strain also promotes a balanced gut microbiome and supports colon health.12-14 Akkermansia muciniphila AH39: This unique strain targets the mucosal layer of the gut, which is critical for supporting healthy gut barrier integrity and promoting healthy inflammatory markers.15,16 This strain’s role in modulating the gut microbiota also contributes to supporting healthy metabolic outcomes and weight management.17-19 Clostridium butyricum: As a producer of butyrate, a key SCFA, Clostridium butyricum supports the health of the intestinal lining by providing energy to colonocytes, promoting healthy inflammatory markers, and supporting gut barrier function.20,21 This strain contributes to a healthy immune response by promoting healthy inflammatory markers, thereby supporting a balanced immune system and gut health.